原料药 API
具备 GMP / DMF 注册就绪度的原料药(API)与候选药物 · 每条标明用途、适应症与为何值得上线
Listing Logic · Why These Products
This category is not a mere directory listing—each product is selected against the four criteria below and comes with both its 'use' and 'why it is listed' so buyers can quickly assess fit. Products are drawn from Unibest's API & Candidates supply catalog and posted after dual qualification and demand screening.
We prioritize APIs already GMP/DMF-ready that can directly support regulatory filing, avoiding the compliance cost of building from scratch.
We target chronic long-term therapies, (WHO) public-health procurement and specialty must-have scenarios with low, predictable demand volatility.
We include first-in-class mechanisms, first approvals or molecules addressing resistance/unmet need, offering differentiated pricing power.
We also tag the number of linked intermediates—deeper in-house intermediate coverage means higher feasibility for scale-up and cost reduction.
Browse by Indication
Pick a class to see only APIs for that disease areaDiabetes, obesity, dyslipidemia, NASH and other metabolic diseases
Hypertension, heart failure, anticoagulation, chronic kidney disease
Solid tumours, haematologic malignancies, myeloproliferative diseases
Antiviral, antibacterial, antifungal, HIV / hepatitis
RA, psoriasis, atopic dermatitis, IBD
Epilepsy, pain, depression & anxiety, neurodegeneration
Acid-related, GI motility, diarrhoea, liver disease
COPD, asthma and other airway diseases
Menopausal symptoms, urological conditions
Glaucoma, ocular surface disease
Skin infection, dermatologic inflammation
Local anaesthesia, postoperative analgesia
Allergic rhinitis, urticaria
Companion-animal ectoparasiticides
Browse by Patent Expiry
The cliff decides when to act — filter by window firstCompound patent expired — generic sourcing and registration feasible
Cliff approaching — lock in API supply and filing schedule early
Mid-term opportunity — start process development and DMF work
Still on-patent — typically licensing or clinical supply
No expiry on file — request a patent assessment for this molecule
Expiry years are compiled from public sources and estimated on compound patents in major markets (US / EU). They exclude polymorph, process and formulation patents, term extensions and paediatric exclusivity. Values marked indicative are directional; values marked to-verify are inferred from filing era. Actual generic entry timing depends on national patent offices and the Orange Book.
Dapagliflozin Propanediol Monohydrate
Glycemic control in type 2 diabetes; reduces heart-failure hospitalization and slows chronic kidney disease progression
A cornerstone SGLT2 inhibitor spanning diabetes, heart failure and CKD (triple indication) with substantial global demand; GMP/DMF-ready and ideal for driving API sourcing through finished-dose registration.
- CAS
- 960404-48-2
- Therapeutic Area
- Endocrine / Cardio-Renal Metabolism
- Target / Mechanism
- SLC5A2
- Labeled Purity
- 99%+
- Patent scope
- Compound patent in major markets (EU earlier; US incl. paediatric exclusivity to 2025)
Letermovir
Prophylaxis of cytomegalovirus (CMV) infection in adult recipients of allogeneic hematopoietic stem cell transplant
A first-in-class CMV terminase inhibitor replacing older ganciclovir-class agents with a better safety profile; a niche, high-value specialty API with limited competition.
- CAS
- 917389-32-3
- Therapeutic Area
- Anti-infective / Transplant
- Labeled Purity
- 98%+
- Patent scope
- US / EU compound patent
Baloxavir Marboxil
Single-dose oral treatment and post-exposure prophylaxis of influenza A and B
A novel single-oral-dose influenza agent with concentrated seasonal demand; integrated API-to-finished supply is attractive for regional pandemic stockpiling.
- CAS
- 1985606-14-1
- Therapeutic Area
- Anti-infective / Antiviral
- Labeled Purity
- 98%+
- Patent scope
- Compound patent in major markets
Finerenone
Chronic kidney disease (CKD) associated with type 2 diabetes; slows renal function decline and cardiovascular events
The first nonsteroidal mineralocorticoid receptor antagonist (nsMRA), filling an anti-inflammatory and anti-fibrotic gap in diabetic kidney disease and recommended by major guidelines, a clearly incremental new product.
- CAS
- 1050477-31-0
- Therapeutic Area
- Cardio-Renal Metabolism
- Target / Mechanism
- NR3C2
- Labeled Purity
- 99%+
Apalutamide
Non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-sensitive prostate cancer
A core endocrine therapy for prostate cancer requiring continuous long-term dosing, ensuring stable annual API demand and well suited to long-term FSO supply arrangements.
- CAS
- 956104-40-8
- Therapeutic Area
- Oncology / Urology
- Target / Mechanism
- AR
- Labeled Purity
- 98%+
Ruxolitinib
Myelofibrosis and polycythemia vera; topical formulations for vitiligo and atopic dermatitis
A foundational agent in myelofibrosis with continued dermatology indication expansion; long-marketed with rigid, predictable demand, a low-volatility steady product.
- CAS
- 941678-49-5
- Therapeutic Area
- Oncology / Hematology
- Target / Mechanism
- JAK1·JAK2
- Labeled Purity
- 98%+
- Patent scope
- US compound patent incl. term extension (timing differs by market)
Upadacitinib
Rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis and more
A leading oral targeted therapy in autoimmunity spanning rheumatology, dermatology and gastroenterology, with strong and definable volume upside.
- CAS
- 1310726-60-3
- Therapeutic Area
- Autoimmune / Rheumatology
- Target / Mechanism
- JAK1·JAK2·JAK3·TYK2
- Labeled Purity
- 98%+
Ozenoxacin
Topical treatment of superficial skin bacterial infections such as impetigo
A topical non-fluoroquinolone quinolone targeting resistant Gram-positive bacteria; its pediatric and local-use profile offers differentiation in OTC and pediatric markets.
- CAS
- 245765-41-7
- Therapeutic Area
- Anti-infective / Dermatology
- Labeled Purity
- 98%+
Brinzolamide
Lowering intraocular pressure in open-angle glaucoma and ocular hypertension
Glaucoma requires lifelong therapy, sustaining steady demand for ophthalmic API; frequently combined with beta-blockers, enabling fixed-dose combination registration.
- CAS
- 138890-62-7
- Therapeutic Area
- Ophthalmology
- Target / Mechanism
- CA2
- Labeled Purity
- 98%+
- Patent scope
- Compound patent long expired; mature multi-source generic supply
Articaine
Dental infiltration and conduction anesthesia
The preferred dental local anesthetic, fast-acting and highly diffusive, with consumption tied to global dental visits, a high-frequency consumable API.
- CAS
- 23964-58-1
- Therapeutic Area
- Anesthesia / Dentistry
- Target / Mechanism
- SCN1A·SCN5A·SCN4A·SCN7A·SCN2A·+more
- Labeled Purity
- 98%+
- Patent scope
- Compound patent long expired; mature multi-source generic supply
Ropivacaine
Surgical anesthesia and postoperative acute pain management (epidural, nerve block)
A long-acting local anesthetic for enhanced-recovery (ERAS) pathways with lower cardiotoxicity than bupivacaine; growth in day-surgery directly lifts volume.
- CAS
- 84057-95-4
- Therapeutic Area
- Anesthesia / Analgesia
- Target / Mechanism
- SCN1A·SCN5A·SCN4A·SCN7A·SCN2A·+more
- Labeled Purity
- 98%+
- Patent scope
- Compound patent long expired; mature multi-source generic supply
Resmetirom
Non-alcoholic steatohepatitis (MASH/NASH) with hepatic fibrosis
The world's first approved MASH therapy, opening a vast untreated blue-ocean; numerous follow-on pipelines will scale API demand alongside the entire class.
- CAS
- 920509-32-6
- Therapeutic Area
- Metabolism / Hepatology
- Target / Mechanism
- THRB
- Labeled Purity
- 99%+
Fexuprazan
Gastroesophageal reflux disease (GERD) and erosive esophagitis
A next-generation potassium-competitive acid blocker (P-CAB) with faster onset and no food effect versus PPIs, the upgrade direction for acid-related disease.
- CAS
- 1902954-60-2
- Therapeutic Area
- Gastroenterology / Acid-related
- Target / Mechanism
- ATP4A·ATP4B
- Labeled Purity
- 99%+
Edoxaban
Stroke prevention in non-valvular atrial fibrillation; treatment of DVT and pulmonary embolism
A next-generation oral anticoagulant (DOAC) clearly replacing warfarin, with a huge atrial-fibrillation population on chronic therapy, a clearly definable blockbuster.
- CAS
- 480449-70-5
- Therapeutic Area
- Cardiovascular / Anticoagulation
- Target / Mechanism
- F10
- Labeled Purity
- 98%+
- Patent scope
- EU major markets; US later — verify per target country
Bilastine
Relief of allergic rhinitis and chronic urticaria symptoms
A non-sedating second-generation antihistamine with seasonal demand and long-term use; suitable for combination with cold remedies and pediatric syrups.
- CAS
- 202189-78-4
- Therapeutic Area
- Allergy
- Target / Mechanism
- HRH1
- Labeled Purity
- 98%+
- Patent scope
- Compound patent in EU major markets
Semaglutide
Glycemic control in type 2 diabetes and weight management; reduces cardiovascular risk
The most consequential molecule in the GLP-1 class, dual-driven by diabetes and obesity with demand far exceeding capacity; a high-barrier peptide API and our top strategic product.
- CAS
- 910463-68-2
- Therapeutic Area
- Endocrine / Metabolism
- Target / Mechanism
- GLP1R
- Labeled Purity
- 99%+
- Patent scope
- China compound patent expires 2026; US / EU to 2031-2033 — wide divergence
Fezolinetant
Moderate-to-severe vasomotor symptoms (hot flashes) of menopause
The first approved non-hormonal therapy for menopausal hot flashes, with broad scope to replace hormone therapy, a large and long-unmet patient population.
- CAS
- 1629229-37-3
- Therapeutic Area
- Women's Health
- Target / Mechanism
- TACR3
- Labeled Purity
- 99%+
Fluralaner
Long-acting eradication of fleas and ticks in dogs and cats
A mainstream pet parasiticide with single-dose long protection; rising global pet-care spending sustains growing animal-health API demand.
- CAS
- 864731-61-3
- Therapeutic Area
- Animal Health
- Labeled Purity
- 99%+
Afoxolaner
Prevention and treatment of flea, tick and certain mite infestations in dogs and cats
A core oral pet parasiticide with good palatability and monthly dosing, often combined with milbemycin oxime, enabling fixed-combination product lines.
- CAS
- 1093861-60-9
- Therapeutic Area
- Animal Health
- Labeled Purity
- 98%+
Lotilaner
Ectoparasite control in dogs and cats; ophthalmic use for demodex blepharitis
The only isoxazoline expanded into human ophthalmology (demodex blepharitis), combining a steady animal-health base with a human-use upside option.
- CAS
- 1369852-71-0
- Therapeutic Area
- Animal Health / Ophthalmology
- Labeled Purity
- 98%+
Sarolaner
Prevention and treatment of flea, tick and other ectoparasite infestations in dogs and cats
One of several same-class agents, suitable as a combination supply within an animal-health portfolio to meet customers' generic and differentiated sourcing needs.
- CAS
- 1398609-39-6
- Therapeutic Area
- Animal Health
- Labeled Purity
- 98%+
Vonoprazan
Reflux esophagitis, gastric ulcer; eradication of Helicobacter pylori with antibiotics
The first marketed P-CAB with stronger, more durable acid suppression and markedly higher H. pylori eradication; especially sizable demand in high-H. pylori Asian markets.
- CAS
- 881681-00-1
- Therapeutic Area
- Gastroenterology / H. pylori
- Target / Mechanism
- ATP4A·ATP4B
- Labeled Purity
- 99%+
- Patent scope
- Japan compound patent; US later
Iptacopan
Paroxysmal nocturnal hemoglobinuria (PNH), IgA nephropathy and C3 glomerulopathy
The first oral complement-factor-B inhibitor, converting PNH from infusion to oral therapy and expanding into nephrology, a high-value rare-disease molecule.
- CAS
- 1644670-37-0
- Therapeutic Area
- Rare Disease / Nephrology
- Target / Mechanism
- CFB
- Labeled Purity
- 98%+
Itacitinib
Graft-versus-host disease (GVHD) and related hematologic malignancies
Addresses high-unmet need in post-transplant GVHD with a clear mechanism and limited competition, well suited to registration partnerships with transplant centers.
- CAS
- 1334298-90-6
- Therapeutic Area
- Hematology / Transplant
- Target / Mechanism
- JAK1
- Labeled Purity
- 98%+
Supply source: Unibest API & Candidates supply catalog, sourced and delivered by Unibest. Therapeutic area, indication and selection rationale are qualitative summaries based on public drug knowledge for business reference; actual registration availability is subject to DMF/GMP documentation and the technical agreement confirmed at order.