原料药 API
具备 GMP / DMF 注册就绪度的原料药(API)与候选药物 · 每条标明用途、适应症与为何值得上线
Listing Logic · Why These Products
This category is not a mere directory listing—each product is selected against the four criteria below and comes with both its 'use' and 'why it is listed' so buyers can quickly assess fit. Products are drawn from Unibest's API & Candidates supply catalog and posted after dual qualification and demand screening.
We prioritize APIs already GMP/DMF-ready that can directly support regulatory filing, avoiding the compliance cost of building from scratch.
We target chronic long-term therapies, (WHO) public-health procurement and specialty must-have scenarios with low, predictable demand volatility.
We include first-in-class mechanisms, first approvals or molecules addressing resistance/unmet need, offering differentiated pricing power.
We also tag the number of linked intermediates—deeper in-house intermediate coverage means higher feasibility for scale-up and cost reduction.
Browse by Indication
Pick a class to see only APIs for that disease areaDiabetes, obesity, dyslipidemia, NASH and other metabolic diseases
Hypertension, heart failure, anticoagulation, chronic kidney disease
Solid tumours, haematologic malignancies, myeloproliferative diseases
Antiviral, antibacterial, antifungal, HIV / hepatitis
RA, psoriasis, atopic dermatitis, IBD
Epilepsy, pain, depression & anxiety, neurodegeneration
Acid-related, GI motility, diarrhoea, liver disease
COPD, asthma and other airway diseases
Menopausal symptoms, urological conditions
Glaucoma, ocular surface disease
Skin infection, dermatologic inflammation
Local anaesthesia, postoperative analgesia
Allergic rhinitis, urticaria
Companion-animal ectoparasiticides
Browse by Patent Expiry
The cliff decides when to act — filter by window firstCompound patent expired — generic sourcing and registration feasible
Cliff approaching — lock in API supply and filing schedule early
Mid-term opportunity — start process development and DMF work
Still on-patent — typically licensing or clinical supply
No expiry on file — request a patent assessment for this molecule
Expiry years are compiled from public sources and estimated on compound patents in major markets (US / EU). They exclude polymorph, process and formulation patents, term extensions and paediatric exclusivity. Values marked indicative are directional; values marked to-verify are inferred from filing era. Actual generic entry timing depends on national patent offices and the Orange Book.
Zoliflodacin
Uncomplicated gonorrhea, especially resistant Neisseria gonorrhoeae
An oral single-dose agent with a wholly new mechanism against antimicrobial-resistant gonorrhea, a WHO-priority AMR direction with clear public-health procurement demand.
- CAS
- 1620458-09-4
- Therapeutic Area
- Anti-infective / Resistant Bacteria
- Labeled Purity
- 98%+
Vapendavir
Rhinovirus infection, to reduce acute exacerbations in asthma/COPD patients
A capsid-binding inhibitor of rhinovirus that can reduce hospitalizations from COPD/asthma exacerbations, a scarce causal-therapy attempt in respiratory care.
- CAS
- 439085-51-5
- Therapeutic Area
- Anti-infective / Respiratory
- Labeled Purity
- 98%+
Vactosertib
Solid tumors and myelodysplastic syndromes; fibrosis indications in research
A TGF-beta pathway inhibitor valuable both as an immuno-oncology combination component and in fibrosis, a dual-track development asset.
- CAS
- 1352608-82-2
- Therapeutic Area
- Oncology / Fibrosis
- Target / Mechanism
- TGFBR1
- Labeled Purity
- 98%+
Itarnafloxin
Antibacterial treatment of bacterial infectious diseases
A broad-spectrum fluoroquinolone with extensive clinical experience and controllable cost, suited as a mature generic supply for regional markets.
- CAS
- 865311-47-3
- Therapeutic Area
- Anti-infective
- Labeled Purity
- 98%+
Islatravir
Treatment of HIV-1 infection and long-acting pre-exposure prophylaxis (PrEP)
A novel nucleoside reverse-transcriptase translocation inhibitor (NRTTI) with long-acting dosing, the core evolution of HIV treatment and prevention, high strategic value.
- CAS
- 865363-93-5
- Therapeutic Area
- Anti-infective / HIV
- Labeled Purity
- 98%+
Isavuconazole
Invasive aspergillosis and mucormycosis (deep fungal infections)
A broad-spectrum triazole covering both aspergillus and mucor, for critical deep fungal infections in immunocompromised patients, an ICU/hematology must-have replacing amphotericin B.
- CAS
- 241479-67-4
- Therapeutic Area
- Antifungal
- Labeled Purity
- 99%+
- Patent scope
- US / EU compound patent
Ensifentrine
Maintenance treatment of chronic obstructive pulmonary disease (COPD)
The first novel-mechanism inhaled COPD maintenance therapy in over a decade, combining bronchodilation and anti-inflammation, filling the gap after triple therapy.
- CAS
- 298680-25-8
- Therapeutic Area
- Respiratory / COPD
- Target / Mechanism
- PDE3A·PDE3B·PDE4A·PDE4D·PDE4B·+more
- Labeled Purity
- 99%+
Ensartinib
First- and later-line treatment of ALK-positive non-small cell lung cancer
A China-originated ALK inhibitor with globally competitive efficacy and safety, a mature asset for domestic innovative-drug export and licensing.
- CAS
- 1370651-20-9
- Therapeutic Area
- Oncology / Lung Cancer
- Target / Mechanism
- ALK
- Labeled Purity
- 98%+
Berzosertib
Advanced solid tumors (ovarian, NSCLC, etc.) with chemo/radiation sensitization
An ATR inhibitor targeting the DNA-damage-repair pathway, a hot combination strategy with chemo-radiotherapy and PARP inhibitors, strong pipeline extensibility.
- CAS
- 1232416-25-9
- Therapeutic Area
- Oncology / Targeted Therapy
- Target / Mechanism
- ATR
- Labeled Purity
- 98%+
Bemnifosbuvir Sulfate
Treatment of hepatitis C virus (HCV) infection
An NS5B nucleotide analog with pangenotypic activity and a high resistance barrier, an important component of HCV combination and retreatment regimens.
- CAS
- 2241337-84-6
- Therapeutic Area
- Antiviral / Hepatitis
- Labeled Purity
- 98%+
Eltanexor
Myelodysplastic syndromes (MDS) and acute myeloid leukemia
A second-generation XPO1 inhibitor with improved tolerability over the first generation, offering a clear substitution opportunity in elderly AML/MDS.
- CAS
- 1642300-52-4
- Therapeutic Area
- Oncology / Hematology
- Labeled Purity
- 98%+
Elpetrigine
Anticonvulsant treatment of epileptiform and other neuronal hyperexcitability disorders
A voltage-gated sodium-channel modulator for epilepsy; antiepileptic demand is stable in emerging markets, suited as a long-term mature product reserve.
- CAS
- 212778-82-0
- Therapeutic Area
- Neurology
- Target / Mechanism
- SCN2A·SCN3A·CACNA1C·CACNA1S·CACNA1D·+more
- Labeled Purity
- 99%+
Elinzanetant
Non-hormonal treatment of menopausal vasomotor symptoms (hot flashes)
A dual-receptor antagonist expected to further improve efficacy and sleep versus first-generation NK3 agents; a validated segment with large demand.
- CAS
- 929046-33-3
- Therapeutic Area
- Women's Health
- Target / Mechanism
- TACR1·TACR3
- Labeled Purity
- 99%+
Eliprodil
Exploratory indications: neuropathic pain, post-stroke neuroprotection
A selective NR2B-subtype antagonist with fewer psychotropic side effects than traditional NMDA antagonists, a common tool compound for neuroscience research.
- CAS
- 119431-25-3
- Therapeutic Area
- Neurology
- Labeled Purity
- 99%+
- Patent scope
- 1990s compound patent; expired per 20-yr term estimate — to be verified
Elzasonan
Depressive and anxiety disorders
An NK1-receptor-route candidate for mood disorders; psychiatric drugs have long cycles and rigid demand, offering differentiated mechanistic value.
- CAS
- 361343-19-3
- Therapeutic Area
- Psychiatry / Neurology
- Target / Mechanism
- HTR1B·HTR1D
- Labeled Purity
- 98%+
- Patent scope
- 2000s compound patent; expired per 20-yr term estimate — to be verified
Emapunil
Anxiety and other mood disorders
Modulates neurosteroid synthesis via the TSPO pathway, avoiding benzodiazepine dependence, a non-sedating new direction in anxiolysis.
- CAS
- 226954-04-7
- Therapeutic Area
- Psychiatry / Neurology
- Target / Mechanism
- TSPO
- Labeled Purity
- 98%+
- Patent scope
- 2000s compound patent; expired per 20-yr term estimate — to be verified
Trelagliptin Succinate
Glycemic control in type 2 diabetes (once-weekly oral)
The world's first once-weekly oral DPP-4 inhibitor, markedly improving adherence; suited to fixed-dose combination with metformin and aligned with chronic-disease management policy.
- CAS
- 1029877-94-8
- Therapeutic Area
- Endocrine / Metabolism
- Target / Mechanism
- DPP4
- Labeled Purity
- 99%+
Orforglipron
Oral treatment of type 2 diabetes and obesity
An oral small-molecule (non-peptide) GLP-1 agonist, synthetically scalable versus peptide APIs, the most watched next-generation weight-management molecule.
- CAS
- 2212020-52-3
- Therapeutic Area
- Endocrine / Metabolism
- Labeled Purity
- 99%+
Vociprotafib
Targeted therapy of solid tumors carrying MAPK-pathway aberrations
An SHP2 inhibitor confronting KRAS/EGFR resistance, a core combination partner with KRAS inhibitors and EGFR antibodies.
- CAS
- 2172652-48-9
- Therapeutic Area
- Oncology / Targeted Therapy
- Labeled Purity
- 98%+
Vipadenant
Parkinson's disease; also reverses adenosine-pathway tumor immune evasion
An A2A adenosine-receptor antagonist spanning both neurodegeneration and tumor immunotherapy, a dual-scenario molecule with rising research interest.
- CAS
- 442908-10-3
- Therapeutic Area
- 肿瘤免疫 / 神经
- Target / Mechanism
- ADORA2A
- Labeled Purity
- 99%+
- Patent scope
- 2000s compound patent; expired per 20-yr term estimate — to be verified
Vistusertib
Advanced solid tumors with PI3K/mTOR pathway aberrations
The mTOR pathway is a core resistance mechanism in breast and gynecologic cancers; combination regimens with endocrine therapy continue to advance.
- CAS
- 1009298-59-2
- Therapeutic Area
- Oncology / Targeted Therapy
- Target / Mechanism
- MTOR
- Labeled Purity
- 98%+
Devazepide
Exploratory indications related to gastrointestinal motility and appetite regulation
A classic cholecystokinin-receptor antagonist research molecule, commonly used in basic studies of digestion physiology and appetite regulation.
- CAS
- 103420-77-5
- Therapeutic Area
- Gastroenterology / Metabolism
- Labeled Purity
- 99+%
- Patent scope
- 1990s compound patent; expired per 20-yr term estimate — to be verified
Dexecadotril
Symptomatic treatment of acute diarrhea
An anti-secretory antidiarrheal that does not inhibit intestinal motility and pairs with rehydration, widely used in pediatric acute diarrhea.
- CAS
- 112573-72-5
- Therapeutic Area
- Gastroenterology
- Labeled Purity
- 98%+
- Patent scope
- Cadotril-class older product; compound patent expired
Abacavir hydroxyacetate
Antiretroviral combination therapy for HIV-1 infection
A classic nucleoside reverse-transcriptase inhibitor still anchoring AIDS cocktail therapy; long-term must-have in national public-health procurement.
- CAS
- 1446418-48-9
- Therapeutic Area
- Anti-infective / HIV
- Labeled Purity
- 98%+
- Patent scope
- Compound patent long expired; mature multi-source generic supply
Supply source: Unibest API & Candidates supply catalog, sourced and delivered by Unibest. Therapeutic area, indication and selection rationale are qualitative summaries based on public drug knowledge for business reference; actual registration availability is subject to DMF/GMP documentation and the technical agreement confirmed at order.