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原料药 API

具备 GMP / DMF 注册就绪度的原料药(API)与候选药物 · 每条标明用途、适应症与为何值得上线

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Listing Logic · Why These Products

This category is not a mere directory listing—each product is selected against the four criteria below and comes with both its 'use' and 'why it is listed' so buyers can quickly assess fit. Products are drawn from Unibest's API & Candidates supply catalog and posted after dual qualification and demand screening.

Registration-ready

We prioritize APIs already GMP/DMF-ready that can directly support regulatory filing, avoiding the compliance cost of building from scratch.

Definable Demand

We target chronic long-term therapies, (WHO) public-health procurement and specialty must-have scenarios with low, predictable demand volatility.

Mechanistic Rarity

We include first-in-class mechanisms, first approvals or molecules addressing resistance/unmet need, offering differentiated pricing power.

Supply-chain Feasibility

We also tag the number of linked intermediates—deeper in-house intermediate coverage means higher feasibility for scale-up and cost reduction.

Browse by Indication

Pick a class to see only APIs for that disease area

Browse by Patent Expiry

The cliff decides when to act — filter by window first

Expiry years are compiled from public sources and estimated on compound patents in major markets (US / EU). They exclude polymorph, process and formulation patents, term extensions and paediatric exclusivity. Values marked indicative are directional; values marked to-verify are inferred from filing era. Actual generic entry timing depends on national patent offices and the Orange Book.

51 API products · Page 2 / 3
Anti-infectivesAPI (Commercialized)To be assessed

Zoliflodacin

Use · Indication

Uncomplicated gonorrhea, especially resistant Neisseria gonorrhoeae

Why Listed

An oral single-dose agent with a wholly new mechanism against antimicrobial-resistant gonorrhea, a WHO-priority AMR direction with clear public-health procurement demand.

CAS
1620458-09-4
Therapeutic Area
Anti-infective / Resistant Bacteria
Labeled Purity
98%+
Novel Topoisomerase InhibitorResistant Gonorrhea单剂口服
View profile & regulatory docs →
Anti-infectivesAPI (Commercialized)To be assessed

Vapendavir

Use · Indication

Rhinovirus infection, to reduce acute exacerbations in asthma/COPD patients

Why Listed

A capsid-binding inhibitor of rhinovirus that can reduce hospitalizations from COPD/asthma exacerbations, a scarce causal-therapy attempt in respiratory care.

CAS
439085-51-5
Therapeutic Area
Anti-infective / Respiratory
Labeled Purity
98%+
Capsid InhibitorRhinovirusRespiratory Indication
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Oncology / HematologyAPI (Commercialized)To be assessed

Vactosertib

Use · Indication

Solid tumors and myelodysplastic syndromes; fibrosis indications in research

Why Listed

A TGF-beta pathway inhibitor valuable both as an immuno-oncology combination component and in fibrosis, a dual-track development asset.

CAS
1352608-82-2
Therapeutic Area
Oncology / Fibrosis
Target / Mechanism
TGFBR1
Labeled Purity
98%+
TGF-beta Receptor InhibitorImmuno-combinationDual Potential
View profile & regulatory docs →
Anti-infectivesAPI (Commercialized)To be assessed

Itarnafloxin

Use · Indication

Antibacterial treatment of bacterial infectious diseases

Why Listed

A broad-spectrum fluoroquinolone with extensive clinical experience and controllable cost, suited as a mature generic supply for regional markets.

CAS
865311-47-3
Therapeutic Area
Anti-infective
Labeled Purity
98%+
Fluoroquinolone ClassOral Antibacterial
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Anti-infectivesAPI (Commercialized)To be assessed

Islatravir

Use · Indication

Treatment of HIV-1 infection and long-acting pre-exposure prophylaxis (PrEP)

Why Listed

A novel nucleoside reverse-transcriptase translocation inhibitor (NRTTI) with long-acting dosing, the core evolution of HIV treatment and prevention, high strategic value.

CAS
865363-93-5
Therapeutic Area
Anti-infective / HIV
Labeled Purity
98%+
Long-acting NRTTIHIV Treatment/PreventionLow-frequency Dosing
View profile & regulatory docs →
Anti-infectivesAPI (Commercialized)Expiring within 2 yrs · 2027 (indicative)

Isavuconazole

Use · Indication

Invasive aspergillosis and mucormycosis (deep fungal infections)

Why Listed

A broad-spectrum triazole covering both aspergillus and mucor, for critical deep fungal infections in immunocompromised patients, an ICU/hematology must-have replacing amphotericin B.

CAS
241479-67-4
Therapeutic Area
Antifungal
Labeled Purity
99%+
Patent scope
US / EU compound patent
Broad-spectrum TriazoleDeep MycosisCritical Care
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RespiratoryAPI (Commercialized)To be assessed6 intermediates

Ensifentrine

Use · Indication

Maintenance treatment of chronic obstructive pulmonary disease (COPD)

Why Listed

The first novel-mechanism inhaled COPD maintenance therapy in over a decade, combining bronchodilation and anti-inflammation, filling the gap after triple therapy.

CAS
298680-25-8
Therapeutic Area
Respiratory / COPD
Target / Mechanism
PDE3A·PDE3B·PDE4A·PDE4D·PDE4B·+more
Labeled Purity
99%+
PDE3/4 Dual InhibitorInhaled DeliveryNovel Mechanism
View 6 key intermediates and enquire →
Oncology / HematologyAPI (Commercialized)To be assessed

Ensartinib

Use · Indication

First- and later-line treatment of ALK-positive non-small cell lung cancer

Why Listed

A China-originated ALK inhibitor with globally competitive efficacy and safety, a mature asset for domestic innovative-drug export and licensing.

CAS
1370651-20-9
Therapeutic Area
Oncology / Lung Cancer
Target / Mechanism
ALK
Labeled Purity
98%+
ALK InhibitorNSCLCDomestic Innovation Going Global
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Oncology / HematologyAPI (Commercialized)To be assessed

Berzosertib

Use · Indication

Advanced solid tumors (ovarian, NSCLC, etc.) with chemo/radiation sensitization

Why Listed

An ATR inhibitor targeting the DNA-damage-repair pathway, a hot combination strategy with chemo-radiotherapy and PARP inhibitors, strong pipeline extensibility.

CAS
1232416-25-9
Therapeutic Area
Oncology / Targeted Therapy
Target / Mechanism
ATR
Labeled Purity
98%+
ATR InhibitorDNA Damage RepairCombination Sensitization
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Anti-infectivesCandidate (In-research)To be assessed

Bemnifosbuvir Sulfate

Use · Indication

Treatment of hepatitis C virus (HCV) infection

Why Listed

An NS5B nucleotide analog with pangenotypic activity and a high resistance barrier, an important component of HCV combination and retreatment regimens.

CAS
2241337-84-6
Therapeutic Area
Antiviral / Hepatitis
Labeled Purity
98%+
NS5B Polymerase InhibitorPangenotypicCombination Regimen
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Oncology / HematologyAPI (Commercialized)To be assessed

Eltanexor

Use · Indication

Myelodysplastic syndromes (MDS) and acute myeloid leukemia

Why Listed

A second-generation XPO1 inhibitor with improved tolerability over the first generation, offering a clear substitution opportunity in elderly AML/MDS.

CAS
1642300-52-4
Therapeutic Area
Oncology / Hematology
Labeled Purity
98%+
XPO1 InhibitorNuclear Export InhibitionHematologic Malignancy
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CNS / PsychiatryAPI (Commercialized)To be assessed

Elpetrigine

Use · Indication

Anticonvulsant treatment of epileptiform and other neuronal hyperexcitability disorders

Why Listed

A voltage-gated sodium-channel modulator for epilepsy; antiepileptic demand is stable in emerging markets, suited as a long-term mature product reserve.

CAS
212778-82-0
Therapeutic Area
Neurology
Target / Mechanism
SCN2A·SCN3A·CACNA1C·CACNA1S·CACNA1D·+more
Labeled Purity
99%+
Sodium Channel BlockerAntiepileptic
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Urology / Women's HealthAPI (Commercialized)To be assessed9 intermediates

Elinzanetant

Use · Indication

Non-hormonal treatment of menopausal vasomotor symptoms (hot flashes)

Why Listed

A dual-receptor antagonist expected to further improve efficacy and sleep versus first-generation NK3 agents; a validated segment with large demand.

CAS
929046-33-3
Therapeutic Area
Women's Health
Target / Mechanism
TACR1·TACR3
Labeled Purity
99%+
NK1/NK3 Dual Antagonist非激素更年期
View 9 key intermediates and enquire →
CNS / PsychiatryAPI (Commercialized)Off-patent · 2020 (to verify)

Eliprodil

Use · Indication

Exploratory indications: neuropathic pain, post-stroke neuroprotection

Why Listed

A selective NR2B-subtype antagonist with fewer psychotropic side effects than traditional NMDA antagonists, a common tool compound for neuroscience research.

CAS
119431-25-3
Therapeutic Area
Neurology
Labeled Purity
99%+
Patent scope
1990s compound patent; expired per 20-yr term estimate — to be verified
NMDA NR2B AntagonistNeuroprotection
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CNS / PsychiatryAPI (Commercialized)Off-patent · 2020 (to verify)

Elzasonan

Use · Indication

Depressive and anxiety disorders

Why Listed

An NK1-receptor-route candidate for mood disorders; psychiatric drugs have long cycles and rigid demand, offering differentiated mechanistic value.

CAS
361343-19-3
Therapeutic Area
Psychiatry / Neurology
Target / Mechanism
HTR1B·HTR1D
Labeled Purity
98%+
Patent scope
2000s compound patent; expired per 20-yr term estimate — to be verified
NK1 AntagonistMood Disorder
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CNS / PsychiatryAPI (Commercialized)Off-patent · 2020 (to verify)

Emapunil

Use · Indication

Anxiety and other mood disorders

Why Listed

Modulates neurosteroid synthesis via the TSPO pathway, avoiding benzodiazepine dependence, a non-sedating new direction in anxiolysis.

CAS
226954-04-7
Therapeutic Area
Psychiatry / Neurology
Target / Mechanism
TSPO
Labeled Purity
98%+
Patent scope
2000s compound patent; expired per 20-yr term estimate — to be verified
TSPO LigandNon-benzodiazepineAnxiolytic
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Metabolic / EndocrineCandidate (In-research)To be assessed

Trelagliptin Succinate

Use · Indication

Glycemic control in type 2 diabetes (once-weekly oral)

Why Listed

The world's first once-weekly oral DPP-4 inhibitor, markedly improving adherence; suited to fixed-dose combination with metformin and aligned with chronic-disease management policy.

CAS
1029877-94-8
Therapeutic Area
Endocrine / Metabolism
Target / Mechanism
DPP4
Labeled Purity
99%+
DPP-4 InhibitorWeekly FormulationAdherence Advantage
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Metabolic / EndocrineAPI (Commercialized)To be assessed23 intermediates

Orforglipron

Use · Indication

Oral treatment of type 2 diabetes and obesity

Why Listed

An oral small-molecule (non-peptide) GLP-1 agonist, synthetically scalable versus peptide APIs, the most watched next-generation weight-management molecule.

CAS
2212020-52-3
Therapeutic Area
Endocrine / Metabolism
Labeled Purity
99%+
Oral Small-molecule GLP-1Non-peptideManufacturing Advantage
View 23 key intermediates and enquire →
Oncology / HematologyAPI (Commercialized)To be assessed

Vociprotafib

Use · Indication

Targeted therapy of solid tumors carrying MAPK-pathway aberrations

Why Listed

An SHP2 inhibitor confronting KRAS/EGFR resistance, a core combination partner with KRAS inhibitors and EGFR antibodies.

CAS
2172652-48-9
Therapeutic Area
Oncology / Targeted Therapy
Labeled Purity
98%+
SHP2 InhibitorOvercoming Resistance
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CNS / PsychiatryAPI (Commercialized)Off-patent · 2020 (to verify)

Vipadenant

Use · Indication

Parkinson's disease; also reverses adenosine-pathway tumor immune evasion

Why Listed

An A2A adenosine-receptor antagonist spanning both neurodegeneration and tumor immunotherapy, a dual-scenario molecule with rising research interest.

CAS
442908-10-3
Therapeutic Area
肿瘤免疫 / 神经
Target / Mechanism
ADORA2A
Labeled Purity
99%+
Patent scope
2000s compound patent; expired per 20-yr term estimate — to be verified
A2A Receptor AntagonistImmuno-combinationNeurodegeneration
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Oncology / HematologyAPI (Commercialized)To be assessed

Vistusertib

Use · Indication

Advanced solid tumors with PI3K/mTOR pathway aberrations

Why Listed

The mTOR pathway is a core resistance mechanism in breast and gynecologic cancers; combination regimens with endocrine therapy continue to advance.

CAS
1009298-59-2
Therapeutic Area
Oncology / Targeted Therapy
Target / Mechanism
MTOR
Labeled Purity
98%+
mTOR InhibitorPI3K/AKT Pathway
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Gastroenterology / HepatologyAPI (Commercialized)Off-patent · 2020 (to verify)

Devazepide

Use · Indication

Exploratory indications related to gastrointestinal motility and appetite regulation

Why Listed

A classic cholecystokinin-receptor antagonist research molecule, commonly used in basic studies of digestion physiology and appetite regulation.

CAS
103420-77-5
Therapeutic Area
Gastroenterology / Metabolism
Labeled Purity
99+%
Patent scope
1990s compound patent; expired per 20-yr term estimate — to be verified
CCK-B AntagonistGI/Appetite
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Gastroenterology / HepatologyAPI (Commercialized)Off-patent · 2015 (indicative)

Dexecadotril

Use · Indication

Symptomatic treatment of acute diarrhea

Why Listed

An anti-secretory antidiarrheal that does not inhibit intestinal motility and pairs with rehydration, widely used in pediatric acute diarrhea.

CAS
112573-72-5
Therapeutic Area
Gastroenterology
Labeled Purity
98%+
Patent scope
Cadotril-class older product; compound patent expired
Enkephalinase InhibitorAnti-secretory AntidiarrhealCommonly Used in Pediatrics
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Anti-infectivesCandidate (In-research)Off-patent · 2012

Abacavir hydroxyacetate

Use · Indication

Antiretroviral combination therapy for HIV-1 infection

Why Listed

A classic nucleoside reverse-transcriptase inhibitor still anchoring AIDS cocktail therapy; long-term must-have in national public-health procurement.

CAS
1446418-48-9
Therapeutic Area
Anti-infective / HIV
Labeled Purity
98%+
Patent scope
Compound patent long expired; mature multi-source generic supply
NRTIHIV Combination TherapyLong-term Therapy
View profile & regulatory docs →

Supply source: Unibest API & Candidates supply catalog, sourced and delivered by Unibest. Therapeutic area, indication and selection rationale are qualitative summaries based on public drug knowledge for business reference; actual registration availability is subject to DMF/GMP documentation and the technical agreement confirmed at order.