Vonoprazan
Reflux esophagitis, gastric ulcer; eradication of Helicobacter pylori with antibiotics
- CAS No.
- 881681-00-1
- Indication Class
- Gastroenterology / Hepatology
- Patent Expiry
- Off-patent · 2026 (indicative)
- Therapeutic Area
- Gastroenterology / H. pylori
- Target / Mechanism
- ATP4A·ATP4B
- Labeled Purity
- 99%+
- Registration Readiness
- GMP/DMF
- Commercialization Tier
- API (Commercialized)
- Linked Intermediates
- Confirm per inquiry
- Patent Scope
- Japan compound patent; US later
Key Intermediates for This API
Order: listed intermediates that accept enquiries first; fragments shared across several APIs rank higherNo intermediate entries are on file for this API yet. You can still enquire by CAS number — we will route it to the supply side for manual sourcing.
Listing Logic · Why It's Worth Listing
The first marketed P-CAB with stronger, more durable acid suppression and markedly higher H. pylori eradication; especially sizable demand in high-H. pylori Asian markets.
Gastroenterology / H. pylori · Marketed; available for immediate sourcing
GMP/DMF-ready; supports regulatory filing and audit in target markets
Intermediates confirmed per inquiry
Product Description
Vonoprazan is a medication belonging to the potassium-competitive acid blocker (PCAB) class. It is used for treating stomach and duodenal ulcers as well as for eradicating Helicobacter pylori infection when used in combination with antibiotics. Unlike traditional proton-pump inhibitors (PPIs), vonoprazan does not require activation in an acidic environment. It directly and reversibly inhibits the proton pump in gastric parietal cells, leading to a more potent, rapid, and prolonged suppression of gastric acid secretion. This makes it particularly effective for conditions like erosive esophagitis and Helicobacter pylori infection.
Supply source: Unibest · Vonoprazan, sourced, vetted and delivered by Unibest. Therapeutic area, indication and listing rationale are qualitative summaries based on public drug knowledge for business reference; actual registration availability and quality specifications are subject to DMF/GMP documentation and the technical agreement confirmed at order.