Unibest 优贝德
Login / Register
API (Commercialized)GMP/DMFEndocrine / Metabolism

Orforglipron

Oral treatment of type 2 diabetes and obesity

CAS No.
2212020-52-3
Indication Class
Metabolic / Endocrine
Patent Expiry
To be assessed
Therapeutic Area
Endocrine / Metabolism
Labeled Purity
99%+
Registration Readiness
GMP/DMF
Commercialization Tier
API (Commercialized)
Linked Intermediates
23 key intermediates available
Oral Small-molecule GLP-1Non-peptideManufacturing Advantage
Enquire by CASAll intermediates →

Key Intermediates for This API

Order: listed intermediates that accept enquiries first; fragments shared across several APIs rank higher
IntermediateCASSharedAction
(2S)-tert-Butyl 3-cyano-2-methyl-4-oxopiperidine-1-carboxylate2212021-56-0—
(4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride2212021-40-2—
(E)-3-(2-(methyl(phenyl)carbamoyl)-1H-indol-5-yl)acrylic acid3047292-97-4—
(R,E)-N-methyl-5-(3-oxo-3-(2-oxo-4-phenyloxazolidin-3-yl)prop-1-en-1-yl)-N-phenyl-1H-indole-2-carboxamide3047293-00-2—
(R)-4-Benzyl-2-oxazolidinone102029-44-7—
(S)-3-Aminobutanenitrile Hydrochloride1073666-54-2—
(S)-5-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-N-methyl-N-phenyl-1H-indole-2-carboxamide2212021-79-7—
1-(4-fluoro-1-methyl-1H-indazole-5-yl)-3-(2-(4-fluoro-3,5-dimethylphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-1,3-dihydro-2H-imidazole-2-one hydrochloride3036782-75-6—
1-(cyanomethyl)-5-[(4S)-2,2-dimethyloxan-4-yl]-N-methyl-N-phenylindole-2-carboxamide2212021-80-0—
1,3,2-Dioxathiolane, 4-Methyl-, 2,2-dioxide, (4R)-1006381-03-8—
2H-Imidazol-2-one, 1-[(4S)-2-(4-fluoro-3,5- dimethylpheny1)-4,5,6,7-2H-Imidazol-2-one, 1-[(4S)-2- (4-fluoro-3,5-dimethylpheny1)-4,5,6,7-1H- indazol-5- yl)- 1,3-dihydro-2212022-56-3—
3-(3-(4-fluoro-1-methyl-1H-indazole-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester3036782-74-5—
5-[(S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl]-1-[(1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl]-1H-indole-2-carboxylic Acid2212021-83-3—
5-Bromo-2-fluoro-m-xylene99725-44-7—
5-Bromo-4-fluoro-1-methyl-1H-indazole1784678-61-0—
5-bromo-N-methyl-N-phenyl-1H-indole-2-carboxamide2860499-50-7—
5-Bromoindole-2-carboxylic acid7254-19-5—
5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 3-(2,3-dihydro-2-oxo-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-2,4,6,7-tetrahydro-4-methyl-, 1,1-dimethylethyl ester, (4S)-2212021-61-7—
H-Indole-2-carboxamide, 1-[(1S,2S)-1-cyano-2-methylcyclopropyl]-N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-2212021-81-1—
N-Boc-L-Alaninol79069-13-9—
tert-buty1 (S)-3-amino-2-(4- fluoro-3,5- dimethylpheny1)-4- methyl-2,4,6,7-tetrahydro-5H-pyrazoloB ,3-c ]pyridine-5-carboxylate2212021-59-3—
tert-butyl 2-(4-fluoro-3,5-dimethylphenyl)-3-(2-oxo-1H-imidazol-3-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate2212022-03-0—
tert-butyl 3-amino-2-(4-fluoro-3,5-dimethylphenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate2212021-41-3—

Listing Logic · Why It's Worth Listing

An oral small-molecule (non-peptide) GLP-1 agonist, synthetically scalable versus peptide APIs, the most watched next-generation weight-management molecule.

Demand

Endocrine / Metabolism · Marketed; available for immediate sourcing

Compliance

GMP/DMF-ready; supports regulatory filing and audit in target markets

Supply

23 key intermediates available; scale-up and cost control manageable

Product Description

Orforglipron is a small molecule (non-peptide) GLP-1 receptor agonist that helps control blood glucose and reduce appetite by mimicking the action of natural GLP-1. It stimulates insulin secretion, inhibits glucagon release, and slows down gastric emptying, primarily used for blood glucose management and long-term weight control (obesity/overweight) in type 2 diabetes.

Supply source: Unibest · Orforglipron, sourced, vetted and delivered by Unibest. Therapeutic area, indication and listing rationale are qualitative summaries based on public drug knowledge for business reference; actual registration availability and quality specifications are subject to DMF/GMP documentation and the technical agreement confirmed at order.