原料药 API
具备 GMP / DMF 注册就绪度的原料药(API)与候选药物 · 每条标明用途、适应症与为何值得上线
Listing Logic · Why These Products
This category is not a mere directory listing—each product is selected against the four criteria below and comes with both its 'use' and 'why it is listed' so buyers can quickly assess fit. Products are drawn from Unibest's API & Candidates supply catalog and posted after dual qualification and demand screening.
We prioritize APIs already GMP/DMF-ready that can directly support regulatory filing, avoiding the compliance cost of building from scratch.
We target chronic long-term therapies, (WHO) public-health procurement and specialty must-have scenarios with low, predictable demand volatility.
We include first-in-class mechanisms, first approvals or molecules addressing resistance/unmet need, offering differentiated pricing power.
We also tag the number of linked intermediates—deeper in-house intermediate coverage means higher feasibility for scale-up and cost reduction.
Browse by Indication
Pick a class to see only APIs for that disease areaDiabetes, obesity, dyslipidemia, NASH and other metabolic diseases
Hypertension, heart failure, anticoagulation, chronic kidney disease
Solid tumours, haematologic malignancies, myeloproliferative diseases
Antiviral, antibacterial, antifungal, HIV / hepatitis
RA, psoriasis, atopic dermatitis, IBD
Epilepsy, pain, depression & anxiety, neurodegeneration
Acid-related, GI motility, diarrhoea, liver disease
COPD, asthma and other airway diseases
Menopausal symptoms, urological conditions
Glaucoma, ocular surface disease
Skin infection, dermatologic inflammation
Local anaesthesia, postoperative analgesia
Allergic rhinitis, urticaria
Companion-animal ectoparasiticides
Browse by Patent Expiry
The cliff decides when to act — filter by window firstCompound patent expired — generic sourcing and registration feasible
Cliff approaching — lock in API supply and filing schedule early
Mid-term opportunity — start process development and DMF work
Still on-patent — typically licensing or clinical supply
No expiry on file — request a patent assessment for this molecule
Expiry years are compiled from public sources and estimated on compound patents in major markets (US / EU). They exclude polymorph, process and formulation patents, term extensions and paediatric exclusivity. Values marked indicative are directional; values marked to-verify are inferred from filing era. Actual generic entry timing depends on national patent offices and the Orange Book.
Finerenone
Chronic kidney disease (CKD) associated with type 2 diabetes; slows renal function decline and cardiovascular events
The first nonsteroidal mineralocorticoid receptor antagonist (nsMRA), filling an anti-inflammatory and anti-fibrotic gap in diabetic kidney disease and recommended by major guidelines, a clearly incremental new product.
- CAS
- 1050477-31-0
- Therapeutic Area
- Cardio-Renal Metabolism
- Target / Mechanism
- NR3C2
- Labeled Purity
- 99%+
Apalutamide
Non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-sensitive prostate cancer
A core endocrine therapy for prostate cancer requiring continuous long-term dosing, ensuring stable annual API demand and well suited to long-term FSO supply arrangements.
- CAS
- 956104-40-8
- Therapeutic Area
- Oncology / Urology
- Target / Mechanism
- AR
- Labeled Purity
- 98%+
Upadacitinib
Rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis and more
A leading oral targeted therapy in autoimmunity spanning rheumatology, dermatology and gastroenterology, with strong and definable volume upside.
- CAS
- 1310726-60-3
- Therapeutic Area
- Autoimmune / Rheumatology
- Target / Mechanism
- JAK1·JAK2·JAK3·TYK2
- Labeled Purity
- 98%+
Ozenoxacin
Topical treatment of superficial skin bacterial infections such as impetigo
A topical non-fluoroquinolone quinolone targeting resistant Gram-positive bacteria; its pediatric and local-use profile offers differentiation in OTC and pediatric markets.
- CAS
- 245765-41-7
- Therapeutic Area
- Anti-infective / Dermatology
- Labeled Purity
- 98%+
Resmetirom
Non-alcoholic steatohepatitis (MASH/NASH) with hepatic fibrosis
The world's first approved MASH therapy, opening a vast untreated blue-ocean; numerous follow-on pipelines will scale API demand alongside the entire class.
- CAS
- 920509-32-6
- Therapeutic Area
- Metabolism / Hepatology
- Target / Mechanism
- THRB
- Labeled Purity
- 99%+
Fexuprazan
Gastroesophageal reflux disease (GERD) and erosive esophagitis
A next-generation potassium-competitive acid blocker (P-CAB) with faster onset and no food effect versus PPIs, the upgrade direction for acid-related disease.
- CAS
- 1902954-60-2
- Therapeutic Area
- Gastroenterology / Acid-related
- Target / Mechanism
- ATP4A·ATP4B
- Labeled Purity
- 99%+
Fezolinetant
Moderate-to-severe vasomotor symptoms (hot flashes) of menopause
The first approved non-hormonal therapy for menopausal hot flashes, with broad scope to replace hormone therapy, a large and long-unmet patient population.
- CAS
- 1629229-37-3
- Therapeutic Area
- Women's Health
- Target / Mechanism
- TACR3
- Labeled Purity
- 99%+
Fluralaner
Long-acting eradication of fleas and ticks in dogs and cats
A mainstream pet parasiticide with single-dose long protection; rising global pet-care spending sustains growing animal-health API demand.
- CAS
- 864731-61-3
- Therapeutic Area
- Animal Health
- Labeled Purity
- 99%+
Afoxolaner
Prevention and treatment of flea, tick and certain mite infestations in dogs and cats
A core oral pet parasiticide with good palatability and monthly dosing, often combined with milbemycin oxime, enabling fixed-combination product lines.
- CAS
- 1093861-60-9
- Therapeutic Area
- Animal Health
- Labeled Purity
- 98%+
Lotilaner
Ectoparasite control in dogs and cats; ophthalmic use for demodex blepharitis
The only isoxazoline expanded into human ophthalmology (demodex blepharitis), combining a steady animal-health base with a human-use upside option.
- CAS
- 1369852-71-0
- Therapeutic Area
- Animal Health / Ophthalmology
- Labeled Purity
- 98%+
Sarolaner
Prevention and treatment of flea, tick and other ectoparasite infestations in dogs and cats
One of several same-class agents, suitable as a combination supply within an animal-health portfolio to meet customers' generic and differentiated sourcing needs.
- CAS
- 1398609-39-6
- Therapeutic Area
- Animal Health
- Labeled Purity
- 98%+
Iptacopan
Paroxysmal nocturnal hemoglobinuria (PNH), IgA nephropathy and C3 glomerulopathy
The first oral complement-factor-B inhibitor, converting PNH from infusion to oral therapy and expanding into nephrology, a high-value rare-disease molecule.
- CAS
- 1644670-37-0
- Therapeutic Area
- Rare Disease / Nephrology
- Target / Mechanism
- CFB
- Labeled Purity
- 98%+
Itacitinib
Graft-versus-host disease (GVHD) and related hematologic malignancies
Addresses high-unmet need in post-transplant GVHD with a clear mechanism and limited competition, well suited to registration partnerships with transplant centers.
- CAS
- 1334298-90-6
- Therapeutic Area
- Hematology / Transplant
- Target / Mechanism
- JAK1
- Labeled Purity
- 98%+
Zoliflodacin
Uncomplicated gonorrhea, especially resistant Neisseria gonorrhoeae
An oral single-dose agent with a wholly new mechanism against antimicrobial-resistant gonorrhea, a WHO-priority AMR direction with clear public-health procurement demand.
- CAS
- 1620458-09-4
- Therapeutic Area
- Anti-infective / Resistant Bacteria
- Labeled Purity
- 98%+
Vapendavir
Rhinovirus infection, to reduce acute exacerbations in asthma/COPD patients
A capsid-binding inhibitor of rhinovirus that can reduce hospitalizations from COPD/asthma exacerbations, a scarce causal-therapy attempt in respiratory care.
- CAS
- 439085-51-5
- Therapeutic Area
- Anti-infective / Respiratory
- Labeled Purity
- 98%+
Vactosertib
Solid tumors and myelodysplastic syndromes; fibrosis indications in research
A TGF-beta pathway inhibitor valuable both as an immuno-oncology combination component and in fibrosis, a dual-track development asset.
- CAS
- 1352608-82-2
- Therapeutic Area
- Oncology / Fibrosis
- Target / Mechanism
- TGFBR1
- Labeled Purity
- 98%+
Itarnafloxin
Antibacterial treatment of bacterial infectious diseases
A broad-spectrum fluoroquinolone with extensive clinical experience and controllable cost, suited as a mature generic supply for regional markets.
- CAS
- 865311-47-3
- Therapeutic Area
- Anti-infective
- Labeled Purity
- 98%+
Islatravir
Treatment of HIV-1 infection and long-acting pre-exposure prophylaxis (PrEP)
A novel nucleoside reverse-transcriptase translocation inhibitor (NRTTI) with long-acting dosing, the core evolution of HIV treatment and prevention, high strategic value.
- CAS
- 865363-93-5
- Therapeutic Area
- Anti-infective / HIV
- Labeled Purity
- 98%+
Ensifentrine
Maintenance treatment of chronic obstructive pulmonary disease (COPD)
The first novel-mechanism inhaled COPD maintenance therapy in over a decade, combining bronchodilation and anti-inflammation, filling the gap after triple therapy.
- CAS
- 298680-25-8
- Therapeutic Area
- Respiratory / COPD
- Target / Mechanism
- PDE3A·PDE3B·PDE4A·PDE4D·PDE4B·+more
- Labeled Purity
- 99%+
Ensartinib
First- and later-line treatment of ALK-positive non-small cell lung cancer
A China-originated ALK inhibitor with globally competitive efficacy and safety, a mature asset for domestic innovative-drug export and licensing.
- CAS
- 1370651-20-9
- Therapeutic Area
- Oncology / Lung Cancer
- Target / Mechanism
- ALK
- Labeled Purity
- 98%+
Berzosertib
Advanced solid tumors (ovarian, NSCLC, etc.) with chemo/radiation sensitization
An ATR inhibitor targeting the DNA-damage-repair pathway, a hot combination strategy with chemo-radiotherapy and PARP inhibitors, strong pipeline extensibility.
- CAS
- 1232416-25-9
- Therapeutic Area
- Oncology / Targeted Therapy
- Target / Mechanism
- ATR
- Labeled Purity
- 98%+
Bemnifosbuvir Sulfate
Treatment of hepatitis C virus (HCV) infection
An NS5B nucleotide analog with pangenotypic activity and a high resistance barrier, an important component of HCV combination and retreatment regimens.
- CAS
- 2241337-84-6
- Therapeutic Area
- Antiviral / Hepatitis
- Labeled Purity
- 98%+
Eltanexor
Myelodysplastic syndromes (MDS) and acute myeloid leukemia
A second-generation XPO1 inhibitor with improved tolerability over the first generation, offering a clear substitution opportunity in elderly AML/MDS.
- CAS
- 1642300-52-4
- Therapeutic Area
- Oncology / Hematology
- Labeled Purity
- 98%+
Elpetrigine
Anticonvulsant treatment of epileptiform and other neuronal hyperexcitability disorders
A voltage-gated sodium-channel modulator for epilepsy; antiepileptic demand is stable in emerging markets, suited as a long-term mature product reserve.
- CAS
- 212778-82-0
- Therapeutic Area
- Neurology
- Target / Mechanism
- SCN2A·SCN3A·CACNA1C·CACNA1S·CACNA1D·+more
- Labeled Purity
- 99%+
Supply source: Unibest API & Candidates supply catalog, sourced and delivered by Unibest. Therapeutic area, indication and selection rationale are qualitative summaries based on public drug knowledge for business reference; actual registration availability is subject to DMF/GMP documentation and the technical agreement confirmed at order.